Listed below are the 55 US AI startups which have raised $100M or extra in 2025

The AI trade entered 2025 with sturdy momentum. 

There have been 49 startups that raised funding rounds worth $100 million or extra in 2024, per our depend at TechCrunch; three corporations raised multiple “mega-round,” and 7 corporations raised rounds that had been $1 billion in measurement or bigger. 

The trade didn’t decelerate in 2025. Whereas much less corporations raised rounds bigger than $1 billion, 4 — Anthropic raised two rounds over $1 billion — considerably extra corporations raised a number of rounds in comparison with 2024, eight.  

How will 2026 examine? Elon Musk’s xAI introduced a $20 billion Sequence E spherical and Sam Altman’s mind pc interface startup Merge Labs raised a $250 million seed round (with OpenAI because the lead investor) in the first few weeks of 2026, so indicators level to a different sturdy 12 months. After all, it’s nonetheless early; we’ll be watching to see if the momentum continues. 

Listed below are all of the U.S. AI corporations that raised $100 million this 12 months: 

December: 

• Austin, Texas-based Mythic, which builds power-efficient compute for AI, raised a $125 million venture round that was led by DCVC. The spherical was introduced on December 17 and included SoftBank, NEA and Linse Capital, amongst different traders.  

• Chai Discovery introduced a $130 million Series B round on December 15. The spherical valued the corporate that builds AI fashions for biotech and drug discovery at $1.2 billion. Oak HC/FT and Common Catalyst co-led the spherical.  

• Generative media platform Fal introduced its third funding spherical of 2025 on December 9. This $140 million Series D round was led by Sequoia and valued the corporate at greater than $4.5 billion.  

• Unconventional AI announced a monster $475 million seed round led by Lightspeed Enterprise Companions and Andreesen Horowitz on December 8. The spherical valued the one-year-old startup, which is rethinking the inspiration of computer systems within the age of AI, at almost $4.5 billion.  

• Boston-based 7AI, which builds cybersecurity AI brokers, raised a $130 million Series A round that was introduced on December 4. Index Ventures led the spherical with participation from Greylock, Spark Capital and CRV, amongst others.  

November

• All-in-one AI workspace platform Genspark introduced a $275 million Series B round that valued the corporate at $1.25 billion on November 20. The spherical included Emergence Capital Companions, SBI Funding, and LG Know-how Ventures, amongst others.  

• Luma AI, which builds fashions used for photograph and video creation, raised $900 million in a Series C round that valued the startup at $4 billion. The spherical was led by Humain with participation from Andreessen Horowitz, AMD Ventures and Amplify Companions, amongst others.  

• Anysphere, the maker of viral vibe-coding platform Cursor, raised $2.3 billion in a funding round that valued the corporate at $29.3 billion. The spherical was introduced on November 13 and is the corporate’s second funding spherical this 12 months.  

• Parallel, which builds internet infrastructure for AI brokers, raised a $100 million Series A round that was introduced on November 12. The spherical was co-led by Index Ventures and Kleiner Perkins.  

• Healthcare AI agent startup Hippocratic AI raised a $126 million Series C round that valued the corporate at $3.5 billion. The spherical was the corporate’s second this 12 months, was introduced on November 3, and was led by Avenir Progress.  

October

• Fireworks AI, a platform that enables customers to construct AI functions utilizing open supply fashions, raised a $250 million Series C round that was introduced on October 28. The spherical valued the corporate at $4 billion.  

• Enterprise AI startup Uniphore is valued at $2.5 billion after a $260 million Series F round that was introduced on October 22. The spherical included Snowflake Ventures, Nvidia, Databricks Ventures, and AMD, amongst others.  

• Sesame, a voice AI firm, raised a $250 million Series B round co-led by Sequoia and Spark Capital. The spherical was introduced on October 21 and likewise included SignalRank as a participant.  

• Cambridge, Massachusetts’s primarily based OpenEvidence, which builds an AI chatbot for the medical discipline, raised its second funding spherical of 2025. The $200 million Series C round was introduced on October 20 and valued the corporate at $6 billion.  

• Lila Sciences, which is seeking to construct a science superintelligence platform, introduced its second funding spherical of 2025 on October 14. The $350 million Series A round was co-led by Braidwell and Collective International. 

• DeepSeek competitor Reflection AI introduced its second mega-round of the 12 months on October 9. The $2 billion Series B round valued the corporate at $8 billion and was led by Nvidia.  

• EvenUp, which builds AI for the non-public harm authorized discipline, introduced a $150 million Series E round that valued the corporate at extra $2 billion on October 7. The spherical was led by Bessemer with participation from Lightspeed, Bain Capital and SignalFire, amongst others.  

September

• Periodic Labs, which is constructing an AI scientist, introduced a $300 million seed round on September 30. Felicis and Andreessen Horowitz led the spherical with participation from Nvidia, Lightspeed, and Khosla Ventures, amongst others.  

• Cerebras Techniques, an AI infrastructure firm, raised a large $1.1 billion Series G round that valued the corporate at $8.1 billion. The spherical was introduced on September 30 and was co-led by Constancy and Atreides Administration. 

• Modular introduced a $250 million funding round on September 24. The spherical was led by US Modern Know-how Fund with participation from GV, Greylock, and Common Catalyst, amongst others.  

• Distyl AI, which builds AI enterprise software program, raised a $175 million Series B round that was introduced on September 23. This spherical valued the startup at $1.8 billion and included traders like Khosla Ventures and Lightspeed.  

• AI infrastructure startup Upscale AI raised a large $100 million seed round that was co-led by Maverick Silicon and Mayfield. The spherical was introduced on September 17 and likewise included StepStone Group, Stanford College, and Qualcomm Ventures, amongst others.  

• Groq, an AI inference firm, raised a $750 million Series D-3 round that valued the corporate at almost $6.9 billion. The spherical was introduced on September 17 and was led by Disruptive.  

• AI coaching startup Invisible Applied sciences was valued at $2 billion after a $100 million fundraise that was introduced on September 16. The increase was led by Vanara Capital with participation from Greycroft, Tallwoods Capital, and Freestyle Capital, amongst others.  

• Cognition AI, the creator of vibe-coding agent Devin, raised a $400 million Series C round that was introduced on September 8. The spherical was led by Founders Fund and valued the corporate at $10.2 billion. 

• AI Infrastructure startup Baseten raised a $150 million Series D round that valued the corporate at $2.1 billion. The September 5 spherical was led by Bond with participation from CapitalG, IVP and Spark Capital, amongst others.  

• Bret Taylor’s customer support AI agent platform Sierra raised $350 million in a spherical led by Greenoaks Capital. This fundraise was introduced on September 4 and valued Sierra at greater than $10 billion.  

• You.com, a personalised AI search engine, raised a $100 million Series C round led by Cox Enterprises. The spherical was introduced on September 3 and valued the corporate at $1.5 billion.  

• AI analysis lab Anthropic raised its second spherical of 2025 in September. Anthropic introduced a $13 billion Series F round on September 2 that valued the corporate at $183 billion. The spherical was led by Iconiq, Constancy, and Lightspeed.  

August

• Healthcare and housing automation platform EliseAI raised $250 million in a Sequence E spherical that valued the startup at $2.2 billion. The spherical, which was introduced on August 20, was led by Andreessen Horowitz.
• Decart, an AI analysis lab, raised $100 million at a $3.1 billion valuation. The spherical included Sequoia Capital, Benchmark, and Zeev Ventures, amongst others, and was introduced on August 7.

July

• Generative media platform Fal raised a $125 million Series C round led by Meritech Capital Companions. The corporate introduced the spherical, which values Fal at $1.5 billion, on July 31. Salesforce Ventures, Shopify Ventures, Google AI Futures Fund, and others joined the spherical.
• 5-year-old Atmosphere Healthcare, which is constructing an AI healthcare working system, raised a $243 million Series C round that was led by Oak HC/FT and Andreessen Horowitz. Kleiner Perkins, OpenAI Startup Fund, Smash Capital, and others additionally participated within the spherical.
• Reka AI, an AI analysis lab, raised $110 million in a spherical that included Snowflake and Nvidia. The Sequence B spherical was introduced on July 22 and values the corporate at $1 billion.
• AI analysis lab Considering Machines Lab confirmed that it raised $2 billion on July 15. This sizable seed spherical was led by Andreessen Horowitz with participation from Nvidia, Accel, and AMD, amongst others. The spherical values the corporate at $12 billion.
• Cambridge, Massachusetts-based OpenEvidence, which is constructing an AI-powered search instrument for clinicians, raised $210 million at a $3.5 billion valuation. The Sequence B spherical was introduced on July 15 and was led by Kleiner Perkins and GV.
• Harmonic, which is constructing a mathematical reasoning engine, raised a $100 million Series B round led by Kleiner Perkins. The spherical was introduced on July 10 and values the corporate at $875 million.

June

• Healthcare AI unicorn Abridge introduced it raised a $300 million Series E round that values the corporate at $5.3 billion. The spherical was led by Andreessen Horowitz with Khosla Ventures taking part. It was the corporate’s second spherical of 2025.
• Harvey, which builds AI instruments for the authorized trade, introduced it raised its second $300 million round of 2025 on June 23. This newest Sequence E spherical was co-led by Kleiner Perkins and Coatue and brings the corporate’s valuation to $5 billion.
• Healthcare AI startup Tennr introduced it raised a $101 million Series C round led by IVP with participation from Lightspeed Enterprise Companions, GV, and Andreessen Horowitz, amongst others. The spherical values the corporate at $605 million.
• Enterprise search startup Glean continues to rake in money. The corporate introduced a $150 million Series F round on June 10, led by Wellington Administration with participation from Sequoia, Lightspeed Enterprise Companions, and Kleiner Perkins, amongst others. Glean is now valued at $7.25 billion.
• Anysphere, the AI analysis lab behind AI coding instrument Cursor, raised a large $900 million Series C round that values the corporate at almost $10 billion. The spherical was led by Thrive Capital with participation from Andreessen Horowitz, Accel, and DST International.

Could

• AI knowledge labeling startup Snorkel AI introduced a $100 million Series D round on Could 29, valuing the corporate at $1.3 billion. The spherical was led by Addition with participation from Prosperity7 Ventures, Lightspeed Enterprise Companions, and Greylock.
• LMArena, a well-liked, community-driven benchmarking instrument for AI fashions, raised a $100 million seed round that valued the startup at $600 million. The spherical was introduced on Could 21 and was co-led by Andreessen Horowitz and UC Investments. Lightspeed Enterprise Companions, Kleiner Perkins, and Felicis additionally participated, amongst others.
• Las Vegas-based AI infrastructure firm TensorWave introduced a $100 million Series A round on Could 14. The spherical was co-led by Magnetar Capital and AMD Ventures with participation from Prosperity7 Ventures, Nexus Enterprise Companions, and Maverick Silicon.

April

• SandboxAQ closed a $450 million Series E round on April 4 that valued the AI mannequin firm at $5.7 billion. The spherical included Nvidia, Google, and Bridgewater Associates founder Ray Dalio amongst different traders.
• Runway, which creates AI fashions for media manufacturing, raised a $308 million Series D round that was introduced on April 3, valuing the corporate at $3 billion. It was led by Common Atlantic. SoftBank, Nvidia, and Constancy additionally participated.

March

• AI behemoth OpenAI raised a record-breaking $40 billion funding round that valued the startup at $300 billion. This spherical, which closed on March 31, was led by SoftBank with participation from Thrive Capital, Microsoft, and Coatue, amongst others.
• On March 25, Nexthop AI, an AI infrastructure firm, introduced that it had raised a Sequence A spherical led by Lightspeed Enterprise Companions. The $110 million round additionally included Kleiner Perkins, Battery Ventures, and Emergent Ventures, amongst others.
• Cambridge Massachusetts-based Insilico Drugs raised $110 million for its generative AI-powered drug discovery platform as introduced on March 13. This Sequence E spherical valued the corporate at $1 billion and was co-led by Worth Companions and Pudong Chuangtou.
• AI infrastructure firm Celestial AI raised a $250 million Series C round that valued the corporate at $2.5 billion. The March 11 spherical was led by Constancy with participation from Tiger International, BlackRock, and Intel CEO Lip-Bu Tan, amongst others.
• Lila Sciences raised a $200 million seed round because it seems to be to create a science superintelligence platform. The spherical was led by Flagship Pioneering. The Cambridge, Massachusetts-based firm additionally obtained funding from March Capital, Common Catalyst, and ARK Enterprise Fund, amongst others.
• Brooklyn-based Reflection.Ai, which seems to be to construct superintelligent autonomous programs, raised a $130 million Series A round that values the 1-year-old firm at $580 million. The spherical was led by Lightspeed Enterprise Companions and CRV.
• AI coding startup Turing closed a Sequence E spherical on March 7 that valued the startup, which companions with LLM corporations, at $2.2 billion. The $111 million round was led by Khazanah Nasional with participation from WestBridge Capital, Gaingels, and Sozo Ventures, amongst others.
• Protect AI, an AI protection tech startup, raised $240 million in a Sequence F spherical that closed on March 6. This spherical was co-led by L3Harris Applied sciences and Hanwha Aerospace, with participation from Andreessen Horowitz and the US Modern Know-how Fund, amongst others. The spherical valued the corporate at $5.3 billion
• AI analysis and enormous language mannequin firm Anthropic raised $3.5 billion in a Series E round that valued the startup at $61.5 billion. The spherical was introduced on March 3 and was led by Lightspeed with participation from Salesforce Ventures, Menlo Ventures, and Common Catalyst, amongst others.

February

• Collectively AI, which creates open supply generative AI and AI mannequin improvement infrastructure, raised a $305 million Series B round that valued the corporate at $3.3 billion. The February 20 spherical was co-led by Prosperity7 and Common Catalyst with participation from Salesforce Ventures, Nvidia, Lux Capital, and others.
• AI infrastructure firm Lambda raised a $480 million Series D round that was introduced on February 19. The spherical valued the startup at almost $2.5 billion and was co-led by SGW and Andra Capital. Nvidia, G Squared, ARK Make investments, and others additionally participated.
• Abridge, an AI platform that transcribes patient-clinician conversations, was valued at $2.75 billion in a Sequence D spherical that was introduced on February 17. The $250 million round was co-led by IVP and Elad Gil. Lightspeed, Redpoint, and Spark Capital additionally participated, amongst others.
• Eudia, an AI authorized tech firm, raised $105 million in a Series A round led by Common Catalyst. Floodgate, Defy Ventures, and In all places Ventures additionally participated within the spherical along with different VC corporations and quite a few angel traders. The spherical closed on February 13.
• AI {hardware} startup EnCharge AI raised a $100 million Series B round that additionally closed on February 13. The spherical was led by Tiger International with participation from Scout Ventures, Samsung Ventures, and RTX Ventures, amongst others. The Santa Clara-based enterprise was based in 2022.
• AI authorized tech firm Harvey raised a $300 million Series D round that valued the 3-year-old firm at $3 billion. The spherical was led by Sequoia and introduced on February 12. OpenAI Startup Fund, Kleiner Perkins, Elad Gil, and others additionally participated within the increase.

January

• Artificial voice startup ElevenLabs raised a $180 million Series C round that valued the corporate at greater than $3 billion. It was introduced on January 30. The spherical was co-led by Iconiq and Andreessen Horowitz. Sequoia, NEA, Salesforce Ventures, and others additionally participated within the spherical.
• Hippocratic AI, which develops massive language fashions for the healthcare trade, introduced a $141 million Series B round on January 9. This spherical valued the corporate at greater than $1.6 billion and was led by Kleiner Perkins. Andreessen Horowitz, Nvidia, and Common Catalyst additionally participated, amongst others.

This piece was up to date on April 23, June 18, August 27, November 26 and January 19, 2026 to incorporate extra offers.

This piece has been up to date to take away that Abridge is predicated in Pittsburgh; the corporate was based there.